KMID : 0358420070500030486
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Korean Journal of Obstetrics and Gynecology 2007 Volume.50 No. 3 p.486 ~ p.493
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Treatment efficacy of high dose progestin in young women with early stage of endometrial carcinoma
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Cho Yun-Hyun
Suh Dae-Shik Ji Yong-Il Kim Dae-Yeon Kim Jong-Hyeok Kim Yong-Man Kim Young-Tak Nam Joo-Hyun
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Abstract
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Objective: The aim of this study is to investigate the effectiveness of high dose progestins in young patients with early stage of endometrial cancer.
Methods: Between April 1998 and December 2005, 10 women with early stage of endometrial carcinoma were treated with high dose progestins as primary therapy for the purpose of saving fertility.
Results: They took 80~160 mg of megestrol acetate or 500~1,000 mg of medroxyprogesterone acetate per day, and then followed up with the endometrial curettages. Seven patients (70.0%) responded to the treatment. Three patients didn¡¯t respond and so underwent hysterectomy as definite treatment. Four patients were able to become pregnant after completing treatment. No patients died of their disease.
Conclusion: The majority of patients with well-differentiated endometrial adenocarcinoma who underwent conservative treatment with a progestational agent responded to the treatment. High-dose progestin therapy can be used as primary therapy in selected young women with early stage of endometrial carcinoma.
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KEYWORD
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High dose progestin therapy, Early endometrial carcinoma
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